可溶性CD14和发生糖尿病风险:脑卒中地理和种族差异的原因研究 (REGARDS)
Kaileen Cruden1, Katherine Wilkinson2, Debora Kamin Mukaz3
1Larner College of Medicine at the University of Vermont, Burlington, VT 05405, USA.
Journal of the Endocrine Society
|May 31, 2024
概括
可溶性CD14 (sCD14) 与白人成年人糖尿病风险增加有关,但与黑人成年人无关. 在考虑到其他糖尿病风险因素后,白人个体的这种关联减少了.
科学领域:
- 生物标志物和炎症 生物标志物和炎症
- 糖尿病 流行病学 流行病学
- 健康方面的种族差异.
背景情况:
- 可溶性CD14 (sCD14) 是一种炎症生物标志物.
- 与黑人成年人相比,白人成年人观察到较高的sCD14度.
- 升高的sCD14水平与胰岛素抵抗和糖尿病有关,但其在发生糖尿病中的作用需要进一步调查.
研究的目的:
- 调查sCD14水平与患新发糖尿病的风险之间的关联.
- 为了检查这种关联是否在美国大型队列中的黑人和白人成年人之间存在差异.
主要方法:
- 利用了3401名黑人和白人参与中风地理和种族差异原因 (REGARDS) 研究的数据,没有先前存在的糖尿病.
- 采用修改的Poisson回归模型来估计每1SD增加sCD14的发生糖尿病的风险比率 (RR).
- 评估了sCD14和种族之间的潜在相互作用,以确定差异性关联.
主要成果:
- 在平均9.5年的随访期间,记录了460例糖尿病病例.
- 观察到sCD14和种族之间的显著相互作用 (P <.09).
- 较高的sCD14与白人参与者的糖尿病风险增加有关 (RR: 1.15),但与黑人参与者的糖尿病风险增加无关 (RR: 0.96). 在调整了两组临床和社会人口统计学风险因素后,这种关联被减弱了.
结论:
- sCD14与发病糖尿病风险之间的关联是白人成年人特有的,主要是由已确定的糖尿病风险因素解释的.
- 研究结果表明,sCD14可能不是跨种族群体发生糖尿病的独立预测因素.
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