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食道癌的免疫疗法:我们现在在哪里,我们可以去哪里?

Yoshiaki Shoji¹, Kazuo Koyanagi², Kohei Kanamori¹

¹Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa 259-1193, Japan.

World journal of gastroenterology

|May 31, 2024

概括

免疫检查点抑制剂,包括抗PD-1和抗CTLA-4抗体,正在改变食道状细胞癌 (ESCC) 治疗. 了解当前的证据和试验为改善患者的治疗结果提供了未来的前景.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,显著改善了各种恶性瘤的结果.
编程细胞死亡-1 (PD-1) 抑制剂现在是转移性食道状细胞癌 (ESCC) 的标准,并在外科手术环境中显示出希望.
细胞毒性T淋巴细胞相关蛋白4 (CTLA-4) 抑制剂,与PD-1 抑制剂结合,已被批准用于复发性/转移性ESCC.

研究的目的:

审查有关ESCC免疫治疗的现有证据.
分析最近的临床试验,将ICI与化疗结合在不同的治疗环境 (新辅助,辅助,转移性) 中.
讨论提高ESCC治疗策略的未来前景.

主要方法:

在ESCC中免疫检查点抑制剂治疗的文献综述.
对新辅助,辅助和转移性ESCC治疗的临床试验数据的分析.
目前证据的综合和ESCC免疫治疗的未来方向.

主要成果:

反PD-1单克隆抗体已被确立为转移性ESCC的标准护理.
与抗PD-1抗体结合的抗CTLA-4抗体已被批准用于先进的ESCC.
目前正在进行的试验探索ICI与化疗在不同临床阶段的结合.

结论:

对ICI在ESCC中的有效性有全面的了解至关重要.
组合疗法和术后应用对改善患者存活率具有显著的前景.
进一步研究新的组合和治疗策略对于推进ESCC护理至关重要.

关键词:

辅助疗法是一种辅助疗法.抗细胞毒性T淋巴细胞关联蛋白4 4 临床试验中的临床试验.组合疗法是一种联合疗法.食道癌是食道癌的一个类型.免疫检查点抑制剂免疫检查点抑制剂免疫治疗是一种免疫疗法.新辅助疗法是一种新辅助疗法.编程细胞死亡-1-1

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