多模式PA/US成像在类风湿性关节炎:加强与临床分数的相关性
Zhibin Huang1, Dongzhou Liu2, Sijie Mo1
1Department of Ultrasound, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518020, China.
Photoacoustics
|May 31, 2024
概括
多模式光声/超声 (PA/US) 成像显示与类风湿性关节炎 (RA) 疾病活动得分有很强的相关性. 这种新的技术为 RA 患者的关节氧化和微血管化提供了增强的评估.
科学领域:
- 类风湿病学 类风湿病学
- 医疗成像医学成像
- 生物医学工程 生物医学工程
背景情况:
- 精确评估类风湿性关节炎 (RA) 疾病活动是具有挑战性的.
- 多模式光声/超声 (PA/US) 关节成像可视化RA受影响关节的微血管化和氧化.
- 有限的大规模研究阻碍了关节氧化与RA疾病活动的相关性.
研究的目的:
- 探索多式PA/US成像得分与RA疾病活动之间的相关性.
- 评估PA/US成像在治疗RA中的临床适用性.
主要方法:
- 111名RA患者接受了7个小关节的PA/US成像.
- PA和功率多普勒超声波 (PDUS) 信号被半定量评估 (0-3分级).
- 累计的PA和PDUS得分 (PA-sum,PDUS-sum) 和相对氧和 (So2) 模式被计算出来,并与疾病活动指数相关联.
主要成果:
- 帕和得分与DAS28 [ESR],DAS28 [CRP],CDAI和SDAI有很强的相关性 (p < 0.001).
- 对于PA和分数的相关性超过了PDUS和分数的相关性.
- 较高的PA和得分与ESR和SJC28的显著差异有关,在缺氧组中临床得分更高.
结论:
- 多模式PA/US成像显示了推进RA评估的潜力,特别是So2评估.
- PA/US成像提供了关于突组织氧化和疾病活性的见解.
- 需要进一步的多中心研究,采用更大的样本大小来验证研究结果.
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