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前列腺特异抗原和维生素D之间的可能非线性关系:基于横截面数据的机器学习研究.

Jia Shi1, Chunyan Yin2, Jinyi Wu1,3

  • 1Department of public health, Wuhan Fourth Hospital, Qiaokou, Wuhan, 430022, China.

Journal of Cancer
|May 31, 2024
PubMed
概括

这项研究发现,维生素D和前列腺特异性抗原 (PSA) 水平之间存在U形的联系. 最佳的维生素D水平可能会降低PSA,但非常高的水平可能会增加它,建议个性化补充.

关键词:
25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)尼恩斯 (NHANES) 是一个名字.维生素D 维生素D是一种维生素.前列腺癌是前列腺癌.前列腺特异抗原前列腺特异抗原.

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科学领域:

  • 内分泌学 在内分泌学.
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 营养科学 营养科学

背景情况:

  • 关于维生素D与前列腺特异性抗原 (PSA) 之间的关联存在不一致的发现.
  • 了解这种关系对于管理前列腺健康和解释PSA水平至关重要.

研究的目的:

  • 为了研究血清25(OH) D和PSA水平之间的剂量反应和非线性关联.
  • 为了比较基于维生素D状态的PSA水平预测的机器学习模型.

主要方法:

  • 来自国家健康和营养检查调查 (NHANES) 的7174个男性样本的分析.
  • 使用分步后勤回归和受限立方线 (RCS) 分析.
  • 评估了四种用于PSA预测的机器学习模型.

主要成果:

  • 在25(OH) D和PSA之间观察到U形关系.
  • 血抗原水平可能在20-134 ng/mL之间的25(OH) D下降,并在这个范围以上增加.
  • 年龄,BMI和肥胖被确定为显著的PSA风险因素;随机森林模型显示出最好的预测准确性.

结论:

  • 这项研究强调了维生素D和PSA之间复杂的U形关联.
  • 血清25(OH) D水平在20-134 ng/mL之间可能与较低的PSA相关.
  • 机器学习,特别是随机森林,可以帮助预测PSA并指导维生素D补充策略.