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预测激进手术后第三阶段结肠癌患者的治疗失败

Hao Zeng¹, Xuejing Zhong², Wenxin Liu³

¹Department of Gastroenterology and Anorectal Surgery, Longyan First Hospital, Fujian Medical University, Longyan, China.

Frontiers in oncology

|May 31, 2024

概括

在手术后的第三阶段结肠癌患者中,nomogram准确地预测了治疗失败. 这种工具有助于临床医生评估患者的风险,优于传统的TNM分期,可以做出更好的临床决策.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
癌症预后癌症预后

背景情况:

第三阶段结肠癌需要精确的预后工具来进行有效的治疗计划.
识别手术后患有治疗失败高风险的患者对于优化治疗结果至关重要.

研究的目的:

开发和验证用于预测第三阶段结肠癌患者进行彻底手术的治疗失败的诺姆图.
为了比较名图的临床实用性与已建立的TNM分期系统.

主要方法:

从SEER数据库 (2018-2019) 中分析了4,115名第三阶段结肠癌患者的临床因素和生存结果.
使用后勤回归开发一个名录,与内部 (7:3分) 和外部队列验证.
使用一致性指数 (C-指数),ROC曲线,校准图,决策曲线分析 (DCA) 和临床影响曲线 (CIC) 评估名录表的性能.

主要成果:

年龄,瘤部位,pT/pN阶段,化疗,CEA水平,淋巴结数,围神经侵袭和婚姻状况被确定为治疗失败的独立预测因素.
诺米图实现了高预测准确度,C指数为0.853 (训练) 和0.841 (测试).
决策曲线分析表明,与TNM分期相比,名图的临床效用优越.

结论:

开发的诺米图谱是一种可靠和准确的工具,用于评估治疗失败的风险,在第三阶段的结肠癌患者的激进手术后.
诺米图提供了超越传统分期方法的强化临床决策支持.

关键词:

监测,流行病学和最终结果 (SEER)对于TNM分阶段系统来说,这是非常重要的.这个名字是名ogramogram.第三阶段结肠癌是什么治疗失败的治疗失败.

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