在老鼠皮层中,晚年并不是慢性皮层内单单元记录的障碍
Nicholas F Nolta1, Michael B Christensen2,3, Patrick A Tresco1
1Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, United States.
Frontiers in neuroscience
|May 31, 2024
概括
这项研究表明,老老鼠的微电极记录性能逐渐下降,但仍然可用于治疗中枢神经系统疾病. 衰老本身并不限制这些神经植入物的使用.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 老年学是一门学科.
背景情况:
- 随着年龄的增长,大脑和免疫系统的变化增加了对神经退行症的易感性.
- 老年人代表了微电极植入物的重要患者群体.
- 了解老年大脑中的设备性能对于临床应用至关重要.
研究的目的:
- 在老老鼠中评估微电极阵列的慢性记录性能.
- 评估老哺乳动物大脑对这些植入物的异体反应 (FBR).
- 为了确定衰老是否会影响神经记录设备的有效性.
主要方法:
- 在18个月大的Sprague Dawley大鼠中植入了临床使用的微电极阵列.
- 在12周内监测慢性记录表现.
- 使用免疫组织化学量化分析了异物反应 (FBR) 和组织变化.
主要成果:
- 单个单元的记录性能在12周内逐渐下降,这与以前在年轻老鼠和人类中发现的结果一致.
- FBR生物标志物的分布与年轻大鼠观察到的分布相似.
- 记录地点附近的星病和组织损失与记录性能相反相关.
结论:
- 老老鼠的神经记录性能呈现逐渐下降,但仍然具有功能.
- 老老鼠的异物反应与年轻老鼠的异物反应相当.
- 衰老并不是穿透微电极阵列在治疗中枢神经系统疾病中的临床使用的限制因素.
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