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Updated: Jun 25, 2025

CD Spectroscopy to Study DNA-Protein Interactions
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一个CAG/CTG重复序列特定结合分子和含有A-A不匹配DNA的复合物的结构研究

Katsuhiko Abe1, Yuki Hirose1, Tomotaka Kumagai1

  • 1Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.

JACS Au
|May 31, 2024
PubMed
概括

烯像聚胺 (PIPs) 通过向异常DNA序列,显示出治疗三重重复疾病的前景. 这项研究揭示了PIP如何结构性地改变引起疾病的DNA,提供了新的治疗见解.

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