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Updated: Jun 25, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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CDK2和CDK4:细胞循环功能发展出不同的,具有催化能力的形状,提供药物点

Wengang Zhang1, Yonglan Liu1, Hyunbum Jang2

  • 1Cancer Innovation Laboratory, National Cancer Institute, Frederick, Maryland 21702, United States.

JACS Au
|May 31, 2024
PubMed
概括

循环素依赖激酶 (CDKs) 控制细胞循环的进展. 这项研究揭示了CDK4/cyclin-D和CDK2/cyclin-E复合体在催化效率上有所不同,影响细胞周期时间,并提供新的药物设计策略.

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