系统性炎症标志物与慢性阻塞性肺病之间的关联:基于人口的研究
Dongru Du1,2, Guangyue Zhang2, Dan Xu1
1Department of Pulmonary and Critical Care Medicine, West China Hospital of Sichuan University and Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, Chengdu, 610041, China.
Heliyon
|May 31, 2024
概括
炎症指数如SII,NLR,PLR和PN与慢性阻塞性肺病 (COPD) 相相关,而LMR显示出负相关性. 这些关联在基于螺旋计和基于问卷的COPD诊断之间有所不同.
科学领域:
- 医学研究 医学研究
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个主要的全球健康问题.
- 炎症在COPD的发病过程中起着至关重要的作用.
- 需要用于COPD评估的新生物标志物.
研究的目的:
- 调查各种炎症指数和COPD之间的相关性.
- 评估系统性免疫炎症指数 (SII),中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),血小板和中性粒细胞计数的产物 (PPN) 和淋巴细胞与单细胞比率 (LMR) 之间的关系.
- 根据COPD诊断标准,探索这些关联中的潜在差异.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据库 (2007-2018) 进行的横截面研究.
- 从血液细胞计数计算SII,NLR,PLR,PNP和LMR的计算和log2转换.
- 基于问卷或螺旋计的COPD诊断.
- 进行了多变量逻辑回归,灵敏度,子组和相互作用分析.
主要成果:
- 总共有23,875名参与者被分析,其中包括1000名COPD患者.
- 在SII,NLR,PLR,PPN和COPD之间发现了积极的关联.
- 在LMR和COPD之间观察到负相关性.
- 具体指数显示,与基于问卷的COPD (NLR,LMR) 相比,与基于螺旋计的COPD (SII,PLR,PNP) 的相关性更强.
结论:
- 多重炎症指数和COPD之间存在显著的关联.
- 在这些关联中,在螺旋计定义和问卷定义的COPD之间注意到了异质性.
- 需要进一步的研究来验证这些发现并探索它们的临床影响.
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