急性-慢性肝病的特征:一个多中心前性队列研究
Yuan-Yao Zhang1, Sen Luo1, Hai Li2
1Department of Infectious Disease, Institute of Biomedical Research, Regulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key Laboratory, Hubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
World journal of hepatology
|May 31, 2024
概括
急性至慢性肝病 (AoCLD) 通常是由HBV感染引起,并由细菌感染引起. 早期诊断和干预对于改善肝硬化急性失补偿 (LC-AD) 或急性至慢性肝衰竭 (ACLF) 患者的生存率至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 急性至慢性肝病 (AoCLD) 占肝病学和传染病部门住院病人的很大一部分.
- 了解AoCLD的不同临床表现和结果对于有效的患者管理至关重要.
研究的目的:
- 描述急性转慢性肝病 (AoCLD),以提高诊断准确性和预后指导.
- 分析不同AoCLD亚型的临床特征,结果和生存率.
主要方法:
- 从中国急性至慢性肝衰竭 (ACLF) 研究中对3375名患有AoCLD的患者进行了大量队列的分析.
- 利用Kaplan-Meier方法和日志等级测试来评估不同AoCLD临床类型的90天生存率.
主要成果:
- 乙型肝炎病毒 (HBV) 感染是慢性肝病 (CLD) 的首要原因 (71.4%),而细菌感染是最常见的原因 (22.8%).
- 肝硬化急性失补偿 (LC-AD) 是最常见的AoCLD亚型 (49.7%),其次是急性至慢性肝衰竭 (ACLF) (25.2%).
- 90天死亡率差异很大:ACLF亚型从27.0%到43.4%,LC-AD为9.0%,肝硬化活性期 (LC-A) 为3.0%,慢性肝炎急性恶化 (CHAE) 为1.2%.
结论:
- 乙型肝炎病毒感染是导致CLD的主要原因,而细菌感染经常会导致AoCLD.
- LC-AD是AoCLD最常见的临床表现.
- 及时诊断和干预对于降低LC-AD和ACLF患者的死亡率至关重要.
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