在心力衰竭患者的左心室功能中,斑点跟踪的胸腔外心回声显示了微妙的变化吗?通过sacubitril-valsartan治疗的减少射出小部分的患者?
Amr Setouhi1, Osama Nady Mohamed2, Hazem M A Farrag1
1Department of Cardiology, Faculty of Medicine, Minia University, Minia, Egypt.
Journal of cardiovascular echography
|May 31, 2024
概括
瓦尔萨坦/萨库比特里尔在心力衰竭中改善了心脏功能,心脏衰竭患者的排气分数减少 (HFrEF). 斑点跟踪回声心电图 (STE) 检测出传统的二维胸前回声心电图 (TTE) 错过的改善.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 心脏衰竭研究研究
背景情况:
- 评估左心室 (LV) 功能的微妙变化对于监测心力衰竭治疗疗效至关重要.
- 瓦尔萨坦/萨库比特里尔是HFrEF的关键治疗方法,需要准确的功能评估.
研究的目的:
- 为了确定瓦尔萨坦/萨库比特利尔对HFrEF患者的LV喷射分数 (EF) 的影响.
- 为了比较2D跨胸心回声学 (TTE) 与2DTTE斑点跟踪 (STE) 在评估6个月瓦尔萨坦/萨库比特里尔治疗后EF变化的疗效.
主要方法:
- 一项前性研究,涉及200名HFrEF患者接受瓦尔萨坦/萨库比特里尔治疗.
- 综合性心脏评估,包括体检,心电图和二维TTE.
- 在治疗6个月之前和之后进行的2D STE评估.
主要成果:
- 瓦尔萨坦/萨库比特里尔治疗使得纽约心脏协会 (NYHA) 的功能类在很大一部分患者中得到改善.
- 41%的患者通过TTE或STE改善了左心室喷射率 (LVEF).
- 在37%的患者中,STE检测到LVEF的改善,这种灵敏度与传统的TTE不匹配.
结论:
- 二维TTE斑点跟踪 (STE) 是一种更可靠的方法来检测早期LVEF改善在HFrEF患者在瓦尔萨坦/萨库比特里尔.
- 与传统的TTE相比,STE在HFrEF中监测治疗反应方面具有更高的灵敏度.
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