年轻和中年成年人的多病态模式和轨迹:一项基于人口的大规模队列研究
Ignatios Ioakeim-Skoufa1,2,3,4,5,6, Francisca González-Rubio3,4, Mercedes Aza-Pascual-Salcedo3,5,7
1Department of Drug Statistics, Division of Health Data and Digitalisation, Norwegian Institute of Public Health, Oslo, Norway.
Frontiers in public health
|May 31, 2024
概括
在18-65岁的成年人中,多种疾病模式很早出现并发展. 高血压和肥胖模式与增加的死亡率有关,强调可预防的心血管风险因素.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 慢性疾病管理 慢性疾病管理
背景情况:
- 多病症,多种慢性疾病的存在,在成年人中很常见.
- 了解多病症模式和轨迹对于有针对性的干预至关重要.
- 大多数研究集中在老年人身上,忽视了年轻人群体中形成的模式.
研究的目的:
- 在18-65岁的成年人中确定多病症模式和轨迹.
- 分析这些模式的演变随着时间的推移.
- 评估模式与死亡率之间的关联.
主要方法:
- 对293923名患有多病症的成年人 (18-65岁) 进行了回顾性的纵向流行病学研究.
- 在基线 (2011) 和后续 (2015,2019) 时对电子健康记录的集群分析.
- 用于可视化轨迹的流图;用于死亡率关联的后勤回归.
主要成果:
- 确定了三个基线模式:失脂症和内分泌代谢,高血压和肥胖,以及不特定的.
- 高血压和肥胖模式 (4人中的1人) 显示4年和8年死亡风险较高.
- 在随访期间,模式不断演变.
结论:
- 可预防的心血管风险因素,特别是高血压和肥胖,是多病症模式的关键,并与较高的死亡率有关.
- 很大一部分患者表现出不特定的疾病模式,需要进一步描述.
- 针对健康老龄化的战略应解决已识别的多病症模式和风险因素.
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