相关实验视频
Updated: Aug 3, 2026

07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
21.1K
多焦点乳头甲状腺癌与不一致的分子驱动器:强调形态和碰撞瘤
Jonathan P Rivera1,2, Yi-Chen Yeh1,3,4, Paul Chih-Hsueh Chen1
1Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
The American journal of surgical pathology
|May 31, 2024
概括
多焦点 papillary 甲状腺癌 (PTC) 的一个小子集显示出不一致的分子驱动因素,通常结合了 BRAF 阳性和酶基因融合相关的 PTC. 识别这些不同的瘤对于量身定制的患者治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 遗传学 遗传学 是一个
背景情况:
- 多焦点 papillary 甲状腺癌 (PTC) 经常携带 BRAF p.V600E 突变.
- 了解多焦点PTC中的分子异质性对于准确的诊断和治疗至关重要.
研究的目的:
- 在当代患者队列中研究具有异调分子驱动力的多焦点PTC.
- 描述这些异质瘤的遗传变化和临床病理特征.
主要方法:
- 在2019-2023年期间,审查诊断出多焦点PTC (≥0.5厘米) 的甲状腺切除试样.
- 针对BRAF VE1,RAS Q61R和针对异常病例的下一代向RNA测序的免疫组织化学 (IHC).
- 形态和分子分析,以识别多焦点PTC中不同的瘤驱动因素.
主要成果:
- 9.2% (13/142) 的多焦点PTC表现出不协调的分子驱动因素.
- 84.6%的不一致病例涉及BRAF阳性和酶基因融合相关的PTCs (例如RET,NTRK,FGFR1) 的组合.
- 不一致的瘤经常表现出不同的形态 (92.3%),发生在对侧叶 (76.9%),30.8%呈现为碰撞瘤. 46.2%的人患有淋巴结转移,2例患者同时患有不和的司机.
结论:
- 多焦点PTC的一个重要子集具有不一致的分子驱动因素,主要是BRAF阳性和激酶基因融合驱动的瘤的混合物.
- 这些瘤经常呈现出不同的形态,并可能涉及淋巴结转移,有时同时由不同的分子亚型.
- 在多焦点PTC中识别不一致的分子驱动因素是临床上重要的,因为它可能具有不同的治疗含义.
相关概念视频
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Cell Migration through Invadopodia
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...

