在患有抗药性的儿童中使用苏:一项回顾性研究
Alexandra Laliberté1, Saoussen Berrahmoune2, Kenneth A Myers2,3,4
1Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec, Canada.
概括
苏胺显示治疗潜力作为药物耐药性的儿童的附加治疗,改善发作频率和降低EEG上的尖峰波指数 (SWI).
科学领域:
- 儿科神经学 儿科神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 临床药理学 临床药理学
背景情况:
- 耐药性在儿科护理中存在重大挑战.
- 确定有效的补充治疗对于管理儿童难以治疗的发作障碍至关重要.
研究的目的:
- 评估苏尔希亚姆作为药物耐药性的儿科患者的辅助治疗的疗效和耐受性.
- 评估苏胺对发作频率和脑电图 (EEG) 参数的影响,特别是尖峰波指数 (SWI).
主要方法:
- 儿童患者的回顾性图表审查,在一个中心接受了11年的苏尔希亚姆治疗.
- 收集的数据包括患者的人口统计学,的特征,治疗史,苏胺剂量和持续时间,不良事件和发作频率.
- 在有数据的情况下,睡眠EEG尖峰波指数 (SWI) 计算在sulthiame启动之前和之后.
主要成果:
- 包括16名患有高度抗药性的儿科患者;大多数患者先前接受过多种抗发作治疗.
- 在12名在基线有活跃发作的患者中,有4人经历了发作频率的改善,其中2人变得没有发作. 在8名患者中,睡眠SWI显著下降,从81.1%降至45.1% (p=0.007).
- 在与NDUFS1和SATB1变异相关的遗传性中发现了积极反应. 常见的不良事件包括昏昏欲睡和攻击性.
结论:
- 苏胺证明了作为儿科耐药性的补充治疗的治疗潜力.
- 对控制和客观EEG测量 (睡眠SWI) 的改进表明,苏在具有挑战性的病例中具有实用性.
- 需要进一步的前性研究来证实这些发现,并确定苏在特定的儿科综合征中的作用.
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