献血中的登革热病毒传播风险:来自泰国的证据
Umaporn Limothai1,2,3, Sasipha Tachaboon1,2,3, Janejira Dinhuzen1,2,3
1Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Journal of medical virology
|May 31, 2024
概括
在泰国献血者中存在无症状登革热病毒 (DENV) 感染,这构成了输血传播的风险. 这凸显了在特有地区加强针对DENV的血液安全措施的需要.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 登革热病毒 (DENV) 感染通常无症状,增加了输血传播 (TT-DENV) 的风险.
- 了解在献血者中DENV的流行率对于确保在特有地区的血液安全至关重要.
研究的目的:
- 调查泰国献血者中的血清流行率和活跃登革热病毒感染的证据.
- 评估与无症状感染相关的TT-DENV的潜在风险.
主要方法:
- 一项横截面研究分析了来自泰国的1053个献血样本 (2020年3月至9月).
- 查包括DENV非结构蛋白1 (NS1) 抗原,以及通过ELISA对抗DENVIgM和IgG抗体.
- 通过RT-PCR,嵌套PCR,病毒隔离和蚊子放大,证实了积极的急性感染标志物 (NS1,IgM).
主要成果:
- 观察到高DENVIgG血清阳性 (89%),表明广泛的过去暴露.
- 在捐赠者中检测到活跃的DENV感染标志物:0.4% (NS1) 和2.1% (IgM).
- 确认测试验证了在捐赠者的子集中存在急性登革热感染的存在.
结论:
- 这项研究证实了健康的泰国献血者中存在无症状登革热病毒感染.
- 这一发现表明,输血传播登革热的风险很大,需要谨慎的血液查方案.
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