在儿科重症监护患者中重复呼吸道吸附培养:频率,耐药性和抗菌素使用情况
Edward Lyon1, Jennifer Goldman1,2, Brian Lee2,3
1Division of Pediatric Infectious Diseases, Children's Mercy Hospital, Kansas City, MO, USA.
在儿科重症监护病房中重复呼吸道吸附体 (TA) 培养通常会产生相同的病原体,并且很少改变抗生素治疗. 然而,这些重复培养可以识别多药耐药生物 (MDROs) 的发展.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 传染病诊断 传染病诊断 传染病诊断
- 抗微生物药物管理管理
背景情况:
- 重复的气管吸附体 (TA) 培养在儿科重症监护室 (PICU) 中很常见.
- 了解这些重复培养的临床效用和影响对于优化患者护理和抗生素使用至关重要.
研究的目的:
- 为了评估重复气管吸附物 (TA) 培养的临床影响.
- 在重症儿童中识别与重复TA培养相关的特征.
主要方法:
- 对接受PICU或CICU治疗的儿童 (≤18岁) 进行回顾性队列研究,具有≥2个TA培养.
- 收集的数据包括人口统计,临床状态,抗生素使用和微生物学.
- 描述性统计分析了培养频率,时间,理由,抗生素暴露和多药耐药生物体 (MDRO) 的发展.
主要成果:
- 63名患者接受了252次重复TA培养,71%在PICU中.
- 平均每名患者获得3种培养,其中50%在7天内获得.
- 66%的患者在多种培养中发现了相同的生物体;抗生素管理很少改变.
结论:
- 在重症儿童中重复TA培养通常可以识别持久的病原体,而无需指导抗生素的变化.
- 这些培养对检测多药耐药生物体 (MDROs) 的出现有价值.
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