遗传预测铁状况与心血管疾病风险之间的关联:孟德尔的随机化研究
Alexa Barad1, Andrew G Clark2,3, Eva K Pressman4
1Division of Nutritional Sciences Cornell University Ithaca NY USA.
Journal of the American Heart Association
|May 31, 2024
概括
较高的铁状况增加了心血管血栓性中风风险,独立于其他心血管疾病因素. 扩张性血压部分调解了这种关联,这表明铁状况是一个可修改的风险因素.
科学领域:
- 心血管流行病学心血管流行病学
- 遗传流行病学遗传流行病学
- 铁的新陈代谢 铁的新陈代谢
背景情况:
- 门德尔随机化 (MR) 研究表明,铁状况影响心血管疾病 (CVD) 风险.
- 对心血管疾病风险因素的仪器变量因类效应的潜在混需要进行调查.
研究的目的:
- 调查铁状况对心血管疾病风险的影响,控制已确定的心血管疾病风险因素.
- 评估CVD风险因素对铁-CVD关联的潜在混或调解作用.
主要方法:
- 进行了两样单变量和多变量门德尔随机化 (MR) 分析.
- 铁生物标记物的仪器变量 (铁的总结合能力,转林和度,血清铁,费里丁) 被使用.
- 研究了与心血管疾病结局 (中风亚型,冠心病) 的关联,并对7个心血管疾病风险因素进行了调整.
主要成果:
- 基因预测较高的铁状况与心血管缺血性中风风险增加有关 (例如,转林和量OR 1.17,血清铁OR 1.21).
- 在对心血管疾病风险因素进行调整后,这些对心血管血栓性中风风险的有害影响仍然存在.
- 透气血压部分介导铁状况对心血管血栓性中风的影响.
- 铁状况对大动脉中风和冠心病的明显保护作用在多变量调整后减少.
结论:
- 铁水平升高与心血管栓塞性缺血性中风的风险较高有关,独立于其他心血管疾病风险因素.
- 扩张压在这种关联中起着部分调解作用.
- 铁状况代表了心血管栓塞性缺血性中风的潜在可修改的风险因素.
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