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Updated: Jun 25, 2025

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转化生长因子β1增强皮质神经元的放电活动

Zhihui Ren1, Tian Li1, Xueer Liu1

  • 1Department of Microbiology and Immunology, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical College, Shantou, Guangdong Province, China.

Neural regeneration research
|May 31, 2024
PubMed
概括

转化生长因子-β1 (TGF-β1) 通过通过MAPK通路调高Nav1.3表达,增加了电压通道 (VGSC) 的电流密度. 这会影响皮层神经元中的神经元发射值,可能导致中枢神经系统疾病.

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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