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新辅助化学辐射对直肠功能的影响,通过直肠测量评估:系统性审查和元分析

Pamela Milito^1,2, Guglielmo Niccolò Piozzi^2,3, Mohammad Iqbal Hussain⁴

¹Department of Emergency and General Surgery, IRCCS Policlinico San Donato, Milan, Italy.

|May 31, 2024

概括

直肠测量没有揭示接受新辅助化学辐射与前期手术的直肠癌患者的显著功能差异. 需要进一步的研究来证实这些关于直肠癌治疗后直肠功能的发现.

科学领域:

结肠直肠外科手术是什么意思
在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

改善直肠癌存活率需要专注于治疗后的直肠功能障碍.
直肠测量可以客观地评估禁欲机制,与主观的生活质量调查问卷不同.
新辅助化学辐射被怀疑会影响直肠癌手术后的直肠功能.

研究的目的:

通过直肠测量测量,评估直肠功能,用于直肠癌患者的直肠癌患者,这些患者经历了完全的中直肠切除术.
为了比较接受新辅助化疗和接受直肠癌前期手术的患者之间的功能结果.

主要方法:

一个系统的审查和对比外科手术期间的直肠计量研究的元分析.
在MEDLINE,Embase和Cochrane数据库中搜索相关研究.
主要结局包括静止压力,挤压压力,感觉值体积和最大可容忍体积.

主要成果:

包括八项研究;七项研究对分析做出了贡献 (共342名患者).
在新辅助化学辐射和前期手术组之间没有观察到静止压力,挤压压力,感觉值体积或最大可容忍体积的统计学上显著差异.
虽然趋势有利于前期手术组,但这些差异缺乏统计学意义.

结论:

来自直肠测量研究的现有证据没有显示新辅助化学辐射和直肠癌前期手术之间的显著功能结果差异.
为了验证这些结果,需要使用标准化新辅助化学辐射和门测量协议进行更大规模的前性研究.

关键词:

阴道直肠测量手术 (anorectal manometry) 是一种用于测量阴道直肠的手术.拉尔斯 (LARS) 是一个功能功能功能新辅助性化疗或放射治疗.

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