Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Additional Subnuclear Structures02:10

Additional Subnuclear Structures

4.6K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
4.6K
The Nucleus01:32

The Nucleus

90.1K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
90.1K
Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

2.7K
Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...
2.7K
Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

2.9K
A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
2.9K
Eukaryotic Compartmentalization01:37

Eukaryotic Compartmentalization

10.9K
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal...
10.9K
Neural Circuits01:25

Neural Circuits

1.1K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Author Correction: Transsynaptic labeling and transcriptional control of zebrafish neural circuits.

Nature neuroscience·2025
Same author

ZNF574 is a quality control factor for defective ribosome biogenesis intermediates.

Molecular cell·2025
Same author

Transsynaptic labeling and transcriptional control of zebrafish neural circuits.

Nature neuroscience·2024
Same author

Brain Imaging and Registration in Larval Zebrafish.

Methods in molecular biology (Clifton, N.J.)·2023
Same author

Specialized neurons in the right habenula mediate response to aversive olfactory cues.

eLife·2021
Same author

Brain-wide cellular resolution imaging of Cre transgenic zebrafish lines for functional circuit-mapping.

eLife·2019
Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026
Same journal

Analysis of dendritic input currents during place field dynamics.

eLife·2026
Same journal

TopoMetry systematically learns and evaluates the latent geometry of single-cell data.

eLife·2026
Same journal

Navigating the path: Advice to physician-scientists on choosing a clinical specialty.

eLife·2026
Same journal

Neural activity profiles reveal overlapping, intermingled subpopulations spanning area borders in mouse sensorimotor cortex.

eLife·2026
Same journal

The exquisite mechanics of a tsetse bite.

eLife·2026
查看所有相关文章

相关实验视频

Updated: Jun 25, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

7.9K

基因定义的内核内核神经元在连接性和功能上有所不同.

Emma D Spikol1,2, Ji Cheng1,3, Michelle Macurak3

  • 1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, United States.

eLife
|May 31, 2024
PubMed
概括
此摘要是机器生成的。

研究人员在斑马鱼核incertus (NI) 中确定了不同的神经元类型,这是一个参与压力和记忆的大脑区域. 这些状本体盒2 (gsc2) 和放松素3a (rln3a) 神经元具有独特的功能和连接性,揭示了NI异质性.

关键词:
这就是CRISPR的敲入式.行为行为行为行为.后脑 后脑 后脑神经电路的神经电路.神经科学 神经科学原子核是不存在的 原子核是不存在的放松素-3是一种放松剂.斑马鱼是一种斑马鱼.

更多相关视频

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
09:02

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

7.4K
Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

2.9K

相关实验视频

Last Updated: Jun 25, 2025

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
10:08

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

7.9K
Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
09:02

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

7.4K
Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

2.9K

科学领域:

  • 神经科学是一个神经科学.
  • 后脑研究 后脑研究
  • 斑马鱼模型 斑马鱼模型

背景情况:

  • 内核 (NI) 是一个保存的后脑结构,对压力,兴奋和记忆至关重要.
  • 它是神经类放松素-3的主要生产基地.
  • 以前的研究还没有完全描述NI内的细胞多样性.

研究的目的:

  • 为了识别和描述斑马鱼NI内的不同神经元群体.
  • 为了研究已识别的NI神经元类型之间的功能和连接性差异.
  • 开发用于精确操纵NI神经元活动的遗传工具.

主要方法:

  • 利用CRISPR/Cas9在斑马鱼中的向整合,专门标记和操纵表达神经元的goosecoid homeobox 2 (gsc2) 和放松素3a (rln3a).
  • 分析了使用投影映射绘制的有机和有机连接模式.
  • 通过成像和行为测试评估自发的神经元活动和功能性质.

主要成果:

  • 根据gsc2和rln3a的表达,在斑马鱼NI中确定了两个不同的神经元,彼此相邻.
  • 证明了gsc2和rln3a神经元的不同投影模式,激活特定的中脑交叉核 (IPN) 亚区域.
  • 展示了不同的激活模式:gsc2神经元对电击有强烈的反应,而rln3a神经元表现出自发的活动和调节的运动行为.

结论:

  • 斑马鱼NI含有异质的神经元群体,具有不同的功能角色.
  • 在NI中,gsc2和rln3a神经元代表了关键的,功能专业化的细胞类型.
  • 这些发现为进一步探索NI电路及其对复杂行为的贡献提供了新的遗传工具.