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Updated: Jun 25, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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合成和RNA的特性 修改与thioamide 核酸间链接

Sayed Habibul Gafur1, Samir Ghosh1, Michael Richter1

  • 1Department of Chemistry, Binghamton University, Binghamton, New York, 13902, USA.

Chembiochem : a European journal of chemical biology
|May 31, 2024
PubMed
概括

化学修改RNA,如胺基,对于RNA疗法至关重要. 短干扰RNA中的thioamide链接显示出与胺相同的双重稳定性和基RNA裂变活性,这表明它们被RNA干扰机制容忍得很好.

关键词:
修改后的siRNA是什么意思RNA骨干的修改是RNA骨干的修改.这是一种RNA干扰.的RNAi特异性.胺是一种胺.

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