脑垂体手术后患有壮症和非功能性脑垂体腺瘤的患者的心血管风险:一个活性-比较队列研究
Melanie Stocker1, Simona E Zimmermann1, Rahel Laager1
1Medical University Department, Division of General Internal and Emergency Medicine, Kantonsspital Aarau, Aarau, Switzerland.
Pituitary
|May 31, 2024
概括
与非功能性垂体腺瘤患者相比,经过垂体手术治疗的壮症患者没有增加心血管风险或死亡率. 外科治疗似乎可以减轻与壮症相关的长期心脏代谢风险.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 神经外科 神经外科
背景情况:
- 巨症与心脏代谢风险增加有关.
- 垂体外科手术是一种常见的治疗缩症和非功能性垂体腺瘤 (NFPA).
研究的目的:
- 为了比较心血管结果,死亡率和壮症患者的住院结果与下垂体手术后的NFPA.
主要方法:
- 在瑞士 (2012-2021) 进行全国性队列研究.
- 使用1:3倾向性比分匹配来比较壮病患者与NFPA患者.
- 主要结局:心血管事件和全因死亡率的组合.
主要成果:
- 在壮症和NFPA组之间的初级复合结局没有显著差异 (HR 0.64;95% CI,0.31-1.32).
- 壮病患者的死亡率在数值上较低 (HR 0.34;95% CI,0.10-1.17).
- 个人心血管事件或住院结果没有显著差异.
结论:
- 与手术治疗的NFPA患者相比,缩症患者的下垂体手术似乎不会增加心血管风险或死亡率.
- 手术治疗可能会抵消以前与壮症相关的心脏代谢风险增加.
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