相关实验视频

Updated: Jun 25, 2025

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

1.5K

复星抑制VDAC1-介导的线粒体功能障碍,以减轻帕金森病模型中的病理进展

Shenglan Feng1, Jianjun Gui1, Bingqing Qin1

  • 1Research Center for Translational Medicine, Hubei Provincial Clinical Research Center for Parkinsons Disease at Xiangyang No.1 Peoples Hospital, Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, 442000, China.

Molecular neurobiology
|May 31, 2024
PubMed
概括

复星 (RES) 通过调节电压依赖性离子通道I (VDAC1) 来改善帕金森病 (PD) 模型中的运动和认知功能. 这种作用减少了α-synuclein积累,并恢复了线粒体功能,为PD提供了潜在的治疗策略.

关键词:
线粒体中的线粒体.帕金森病是帕金森氏症的一种疾病.复星醇是一种复星.在 VDAC1 中,VDAC1 是α-Synuclein 是一种蛋白质.

更多相关视频

Author Spotlight: Decoding Mitochondrial Aging08:48

Author Spotlight: Decoding Mitochondrial Aging

Published on: June 30, 2023

3.8K
Measurement of Oxygen Consumption Rate in Acute Striatal Slices from Adult Mice07:41

Measurement of Oxygen Consumption Rate in Acute Striatal Slices from Adult Mice

Published on: June 8, 2022

4.2K

相关概念视频

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
257
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
527
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
13.0K