相关实验视频

Updated: May 6, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery

Published on: February 14, 2017

造血细胞内皮原生细胞在脑缺血后增强运动功能和皮质运动图的完整性

Aqeela Afzal¹, Nagheme Thomas², Zuha Warraich³

¹Department of Neurological Surgery, Vanderbilt University, Nashville, TN, USA.

Restorative neurology and neuroscience

|May 31, 2024

概括

造血干细胞 (HSC) 改善大鼠中风后的运动功能和皮质地图. 这种治疗可以增强大脑组织功能,以便更好地恢复,即使不减少心脏病发作的大小.

科学领域:

神经科学是一个神经科学.
再生医学是一种再生医学.
脑卒中研究脑卒中研究

背景情况:

已知造血干细胞 (HSC) 迁移到脑损伤部位并有助于恢复.
HSCs改善脑缺血后的结果的确切机制在很大程度上仍未被探索.
了解HSC的影响对于开发新的中风疗法至关重要.

研究的目的:

研究HSC的治疗潜力,改善运动缺陷和皮质功能障碍后脑缺血.
阐明HSCs对脑组织完整性和中风后行为恢复的功能影响.

主要方法:

老鼠经历了一次单边中风,然后被分配到对照组,中风或中风+HSC治疗组.
通过验证的测试 (例如,单颗粒达到,向日种子打开) 评估了运动性能.
皮质内微刺激在运动皮质中映射了前肢运动表征.

主要成果:

脑卒中 + HSC 动物在脑卒中后的3周和5周,与仅脑卒中的动物相比,显著改善了运动技能.
在5周内,在中风+HSC组的向日种子打开任务中观察到更好的表现.
HSC治疗导致前肢运动图显著增加,表明皮质组织有所改善,而不会改变心脏病发作的大小.

结论:

脑卒中后给药HSC可以增强剩余皮质组织的功能能力.
皮质组织的功能完整性改善与中风后更好的行为结果相关.
通过促进功能重组,HSC疗法为中风恢复提供了一个有希望的方法.

关键词:

一次性中风,中风.行为行为行为行为.摩托车地图摩托车地图干细胞是干细胞的组成部分.

更多相关视频

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells

Published on: July 10, 2019

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

相关概念视频

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...