在新诊断的慢性髓性白血病中使用阿西米尼布
Andreas Hochhaus1, Jianxiang Wang1, Dong-Wook Kim1
1From Klinik für Innere Medizin II, Hematology/Oncology, Universitätsklinikum Jena and Comprehensive Cancer Center Central Germany, Campus Jena, Jena (A.H.), and the Department of Oncology and Hematology, Charité-Universitätsmedizin Berlin, Berlin (P.C.) - both in Germany; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China (J.W.); Uijeongbu Eulji Medical Center, Geumo-dong, Uijeongbu-si (D.-W.K.), and the Department of Internal Medicine, Seoul National University Hospital, Biomedical Research Institute, Cancer Research Institute, Seoul National University College of Medicine, Seoul (I.K.) - both in South Korea; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto (D.D.H.K.); the Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, and Masaryk University - both in Brno, Czech Republic (J.M.); the Department of Hematology, Singapore General Hospital, Singapore (Y.-T.G.); the Department of Hematology, Akita University, Akita City, Japan (N.T.); the Hematology Department, Institut Bergonié, Bordeaux (G.E.), and Novartis Pharma, Paris (S.I.) - both in France; Rocky Mountain Cancer Centers, Boulder, CO (D.A.); the Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston (G.C.I.); the University of Chicago, Chicago (R.A.L.); CML Patients Group, CML Advocates Network, Turin, Italy (F.B.); Novartis Pharmaceuticals, East Hanover, NJ (S.K.); Novartis Pharma, Basel, Switzerland (T.M., K.M., L.Y., M.H.); Georgia Cancer Center at Augusta University, Augusta (J.E.C.); and the South Australian Health and Medical Research Institute and University of Adelaide, Adelaide, SA, Australia (T.P.H.).
在新诊断的慢性髓性白血病 (CML) 患者中,阿西米尼布在与研究人员选择的铁激酶抑制剂 (TKIs) 相比,表现出更高的疗效和有利的安全性. 这种新型BCR::ABL1抑制剂为前线CML治疗提供了有前途的替代方案.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性髓性白血病 (CML) 需要有效和安全的长期治疗.
- 阿西米尼布是一种向的BCR::ABL1抑制剂,是标准ATP竞争型铁氨酸激酶抑制剂 (TKI) 的潜在替代品.
- 这项研究评估了阿西米尼布在新诊断的CML患者中的疗效和安全性.
研究的目的:
- 为了比较阿西米尼布的疗效和安全性与前线CML治疗中由研究人员选择的TKI.
- 在48周评估主要分子响应 (MMR) 的初级终点.
主要方法:
- 一项3期随机试验分配了201名患者接受阿西米尼布和204名患者接受研究人员选择的TKIs (imatinib或第二代TKIs).
- 随机化通过风险评分和TKI选择进行了分层.
- 主要终点是在48周的MMR (BCR:ABL1 ≤0.1%IS).
主要成果:
- 阿西米尼布在48周的MMR率 (67.7%) 与研究人员选择的TKIs (49.0%) 相比,实现了显著更高的MMR率.
- 在伊马替尼布层中,阿西米尼布显示出优于伊马替尼布 (40.2%) 的MMR率 (69.3%).
- 与TKIs相比,阿西米尼布显示3级+不良事件 (38.0%) 和治疗中止 (4.5%) 的发生率较低.
结论:
- 阿西米尼布在新诊断的慢性阶段CML中表现出卓越的疗效和有利的安全性.
- 阿西米尼布是前线CML治疗的有希望的选择.
- 与第二代技术知识产权直接比较并不是主要目标.
更多相关视频
11:29HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
05:29A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells
Published on: March 28, 2021
相关概念视频
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Inhibition of Cdk Activity
