骨质保护素在缺血性中风患者的预后效果:系统性审查和元分析
Linlin Pang1, Hongyu Lin2, Xinxian Wei1
1Department of Neurology, Minzu Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi Zhuang Autonomous Region, China.
PloS one
|May 31, 2024
概括
骨质保护素 (OPG) 似乎无法预测缺血性中风 (IS) 后患者的功能性结果或死亡率. 目前的证据不足以确定OPG水平与IS后患者预后之间的联系.
科学领域:
- 心血管科学 心血管科学
- 神经学 神经学
- 生物标志物 生物标志物
背景情况:
- 骨质保护蛋白 (OPG) 与动脉样硬化和心血管疾病有关.
- 在缺血性中风 (IS) 中OPG的预后作用仍然存在争议.
- 这项研究提供了首次对OPG在IS患者的预后效果进行系统性审查和元分析.
研究的目的:
- 评估骨质保护素 (OPG) 在缺血性中风 (IS) 患者的预后意义.
- 为了确定OPG水平是否与IS患者的功能性结果差或死亡率相关.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行了系统的文献搜索,截至2023年8月21日.
- 包括了观察性研究,评估OPG对功能结果 (修改的兰金评分表3-6分) 和IS患者死亡率的影响.
- 调整后的几率比率 (aOR) 和95%置信区间 (CI) 进行了聚合,以评估整体效应.
主要成果:
- 包含4506名患者的5项研究符合纳入标准.
- 聚合分析表明,OPG与功能表现不佳之间没有显著的关联 (aOR 1.29,95% CI 0.90-1.85).
- 同样,OPG与IS患者的死亡率没有显著相关 (aOR 1.57,95% CI 0.90-2.74).
结论:
- 目前还没有足够的证据来证实OPG与IS死亡率或不良功能结果之间的相关性.
- 根据目前的数据,骨质保护素不是基于IS患者神经功能可靠的预测指标.
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