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Updated: Jun 25, 2025

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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Published on: January 14, 2016

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在复制叉上从基底组素H4低乙化逆转增加了FANCA缺陷细胞中的DNA损伤

Benilde García-de Teresa1,2, Cecilia Ayala-Zambrano1,3, Mirna González-Suárez1

  • 1Laboratorio de Citogenética, Instituto Nacional de Pediatría, Mexico City, Ciudad de México, Mexico.

PloS one
|May 31, 2024
PubMed
概括

缺乏FANCA的细胞在复制分叉时表现出低乙化素H4. 使用SAHA抑制基因组脱乙酶会恢复乙化,导致这些FA/BRCA通路受损细胞的DNA损伤和细胞循环停止.

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