格雷夫斯病中的肠道微生物组:抗甲状腺药物治疗前后比较
Chaiho Jeong1, Hansang Baek1, Jaewoong Bae2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
PloS one
|May 31, 2024
概括
格雷夫斯病 (GD) 改变了肠道细菌的多样性和组成. 对GD的抗甲状腺药物 (ATD) 治疗有助于恢复肠道微生物组的平衡,改善甲状腺功能障碍的症状.
科学领域:
- 微生物组研究 微生物组研究
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物组在格雷夫氏病 (GD) 病原发生过程中的作用已被建议,但尚未完全理解.
- 关于抗甲状腺药物 (ATD) 治疗如何影响GD患者的肠道微生物群的研究有限.
研究的目的:
- 在ATD治疗之前和之后调查GD患者肠道微生物组的变化.
- 为了将肠道微生物组成的变化与甲状腺功能,抗体和甲状腺功能过高症状相关联.
主要方法:
- 在基线和ATD治疗6个月后,新诊断的GD患者 (n=29) 的便样本.
- 与来自EMBL核酸序列数据库的健康对照 (HC) 组 (n=230) 的比较.
- 对α多样性,微生物组成 (类,属) 和与临床参数的关联进行分析.
主要成果:
- GD患者的肠道微生物α多样性减少,在ATD治疗后增加到HC水平.
- GD患者的Firmicutes较低,Bacteroidota较高;ATD治疗逆转了这一趋势,类似于HC.
- 像Roseburia和Akkermansia这样的特定品种的GD下降,但在治疗后出现恢复; 无气体类型与吸烟和TSHR-Ab水平相关.
结论:
- 在Graves病中,肠道微生物组发生了显著的变化.
- 治疗ATD可以恢复肠道微生物群的多样性和组成,使其达到健康水平.
- 肠道微生物组调节可能在GD病原和治疗反应中发挥作用.
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