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早期接触抗生素与儿童肥胖的发展之间的关联:意大利的基于人口的研究
Anna Cantarutti1, Paola Rescigno2, Claudia Da Borso1
1Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milano, Italy.
JMIR public health and surveillance
|May 31, 2024
概括
儿童早期接触抗生素与患肥胖的风险更高有关. 这种风险随着处方的增加和早期的抗生素初始使用而增加,这突显了严重的公共卫生问题.
科学领域:
- 儿科健康 儿科健康
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
背景情况:
- 儿童肥胖是一个重大的全球健康挑战.
- 早期的抗生素暴露可能会破坏肠道微生物群,可能会影响肥胖的发展.
研究的目的:
- 调查早期抗生素暴露与儿童肥胖风险之间的联系.
主要方法:
- 这是一项对意大利 (2004-2018) 超过121,000名儿童的回顾性队列研究.
- 分析生命第一年的抗生素处方时间和数量.
- 使用混合效应的考克斯比例危险模型来评估到14岁的肥胖风险.
主要成果:
- 第一年的抗生素暴露与持续增加的肥胖风险有关.
- 随着抗生素处方数量的增加,肥胖的风险显著增加 (P趋势<.001).
- 0-5个月期间使用抗生素对儿童肥胖风险的影响最大.
结论:
- 早期接触抗生素与儿童肥胖的风险增加有关.
- 风险取决于剂量,随着处方的增加和早期开始抗生素治疗而增加.
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