不同的固体颗粒大小对麦蛋白分离物和素颗粒稳定皮克林乳液的影响,以及它们作为输送系统的使用
Ziyun Liu1, Kaiwen Zheng1, Ruizhe Yan1
1College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Food chemistry
|May 31, 2024
概括
麦蛋白分离物/高甲烯复合物有效稳定皮克林乳液用于营养药物输送. 这些复合物增强了黄素的封装和受控释放,提高了其生物可用性.
科学领域:
- 食品科学 食品科学 食品科学
- 合体和表面科学科学
- 材料科学 材料科学 材料科学
背景情况:
- 皮克林乳液由固体颗粒稳定,为传统乳化剂提供了替代品.
- 为皮克林乳液开发有效的稳定剂对于先进的输送系统至关重要.
- 麦蛋白分离物 (OPI) 和高甲烯 (HMP) 是生物相容的生物聚合物,具有复杂形成的潜力.
研究的目的:
- 准备和表征麦蛋白分离物/高甲酸pectin复合物 (OPP).
- 评估OPP作为皮克林乳液稳定剂的有效性.
- 评估OPP稳定皮克林乳液作为库尔库等生物活性化合物的输送系统的潜力.
主要方法:
- 通过不同的OPI:HMP比率和pH来合成OPP,从而影响粒子大小和相互作用.
- 对OPP颗粒大小和形态学的表征.
- 用OPP稳定皮克林乳液的制备和评估,评估界面膜的形成,表面粘度和滴滴大小.
- 在模拟的胃肠道条件下,分析封装效率和OPP稳定乳液中的黄素体内释放率.
主要成果:
- 具有较小颗粒大小 (125.7-297.6 nm) 的 OPP 在有利于疏水和静电相互作用的条件下形成 (OPI:HMP = 3:1, pH 4,5).
- OPP-2通过密集的界面膜形成证明了有效的皮克林乳液稳定,从而产生高表面粘度和小滴滴大小 (23.39微米).
- OPP-2稳定乳液显示了高黄素封装效率 (85.63%) 和受控释放,提高了黄素的生物可访问性.
结论:
- OPP可以有效地稳定皮克林乳液,其特性可以根据OPI:HMP比率和pH调整.
- OPP-2是一种有前途的稳定剂,用于制造高性能皮克林乳液.
- 与OPP稳定的皮克林乳液显示出作为传递系统的显著潜力,可以提高生物活性化合物的生物可用性.
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