适应pH值的氨基化半孔二氧化微球,经大豆皮质多糖化物修饰,用于黄素封装和受控释放
Shumin Wang1, Shengnan Wang2, Lina Yang2
1College of Food Science and Technology, Bohai University, Jinzhou 121013, China.
Food chemistry
|May 31, 2024
概括
研究人员开发了新的半孔微球 (MSM) 和大豆多糖 (SHP) 混合纳米粒子,以增强黄素的输送. 这些适应pH的纳米颗粒显示出更好的加载和受控释放,为向药物输送应用提供了潜在的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 半孔二氧化微球 (MSM) 在生物相容性方面存在局限性.
- 将MSM与聚合物集成的混合材料可以克服单个组件的弱点.
- 开发响应的药物输送系统对于向治疗至关重要.
研究的目的:
- 合成和描述结合MSM和大豆皮聚糖化物 (SHP) 的新型混合纳米粒子.
- 评估黄素 (Cur) 封装效率和开发的纳米粒子的负载能力.
- 为了研究黄素从混合纳米颗粒中的pH响应释放行为.
主要方法:
- 合成的MSM的氨基化.
- 用SHP对氨基化MSM进行修改,以创建MSMs-NH2@SHPs纳米粒子.
- 在体外评估黄素封装,加载率和pH依赖的释放特征.
主要成果:
- MSMs-NH2@SHPs纳米粒子实现了75.58%的高黄素封装效率和35.12%的负载能力.
- 混合纳米颗粒显示与单独的MSMs-NH2相比,黄素负载显著更高 (增加6.95倍).
- 黄素的释放是响应pH的,pH为5.0 (76.21%) 的累积释放率高于pH为7.4 (56.55%) 的累积释放率.
结论:
- 开发的MSMs-NH2@SHPs纳米颗粒提供了卓越的黄素封装和加载效率.
- 这些混合纳米颗粒具有显著的pH敏感药物释放,特别是在轻微酸性环境中.
- 这些发现突出了这些MSM基纳米颗粒在有效和可控的黄素输送方面的潜力.
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