通过皮肤对发作进行耳膜迷走神经刺激
Qing Zhang1, Xue Luo2, Xiao-Hui Wang3
1Department of Neurology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, China.
Seizure
|May 31, 2024
概括
通过皮肤进行耳道迷走神经刺激 (taVNS) 显示出治疗的前景,患者的反应率和EEG变化有所改善. 动物研究证实taVNS有效地减少了性行为和发作频率.
科学领域:
- 神经学 神经学
- 医疗器械 医疗器械
- 综合医学是一个整体的医学.
背景情况:
- 通过皮肤进行迷走神经刺激 (tVNS) 正在探索治疗.
- 耳部针点疗法是一种迷走神经刺激形式,缺乏全面的审查.
- 本综述将耳部针治疗归类为通过皮肤进行的耳部迷走神经刺激 (taVNS).
研究的目的:
- 评估taVNS在患者 (PWE) 的疗效.
- 分析taVNS抗作用的临床前数据.
- 评估taVNS对PWE中电脑电图 (EEG) 变化的影响.
主要方法:
- 9项临床研究和8项临床前研究的系统综述和元分析.
- 搜索了多个数据库 (MEDLINE,EMBASE,科学网,Scopus,中国数据库) 截至2023年6月10日.
- 使用PRISMA 2020检查清单进行研究质量评估.
主要成果:
- 与对照治疗相比,taVNS在PWE中显示出显著更高的响应率 (OR = 2.94).
- 塔VNS组表现出比对照组更明显的EEG变化 (OR = 2.17).
- 临床前研究显示,taVNS的性行为 (SMD = -4.78) 和发作频率 (SMD = -5.06) 显著改善.
结论:
- 患有 (PWE) 的患者可能会从通过皮肤进行的耳道迷走神经刺激 (taVNS) 中获得好处.
- 在动物模型中,taVNS证明有效改善性行为.
- 对管理的taVNS进行进一步的研究是有必要的.
相关概念视频
Hair Cells
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
Sensory Functions of the Skin
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Accessory Structures of the Skin: Hair and Hair Follicles
Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Auditory Pathway
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking the...
Auditory Perception
The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the cochlea, a...


