在海马硬化和MRI阴性叶之间比较自发大脑活动
Chengru Song1, Xiaonan Zhang1, Yong Zhang1
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China; Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China; Key Laboratory of Imaging Intelligence Research Medicine of Henan Province.
海马硬化 (HS) 和MRI阴性叶 (TLE) 分享类似的自发大脑活动 (SBA) 网络障碍,但在HS的TLE中变化更为明显. 这些发现有助于理解TLE亚型和认知影响.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 医疗成像医学成像
背景情况:
- 海马硬化 (HS) 是叶 (TLE) 的常见原因,但30%的TLE病例显示正常的MRI.
- 了解TLE亚型中的大脑活动差异对于临床管理至关重要.
研究的目的:
- 为了比较TLE与HS (TLE-HS) 和MRI阴性TLE (TLE-N) 的静态和动态自发大脑活动 (SBA) 异常.
- 调查SBA变化,持续时间和认知功能之间的相关性.
- 为了确定TLE亚型的潜在差异诊断标记.
主要方法:
- 在38名TLE-HS患者,51名TLE-N患者和53名对照中测量了12个静态和动态SBA指标.
- 使用voxel-wise ANOVA和后 hoc分析进行度量比较.
- 采用ROC分析用于诊断指数和Spearman相关性用于临床关联.
主要成果:
- 无论是TLE-HS还是TLE-N都表现出广泛的SBA网络障碍,其模式重叠.
- 增加了fALFF,dALFF和dfALFF在 mesial叶,thalamus,基底腺,pons和小脑中.
- 在侧叶中减少了fALFF,ReHo,dReHo,DC,GSCorr和VMHC.
- 在TLE-HS中,SBA变化更为明显,在叶中减少了VMHC,与TLE-N.区分开来.
结论:
- 静态和动态SBA指标证实TLE-HS和TLE-N是复杂的网络疾病.
- 在TLE亚型中,类似的SBA异常模式涉及与TLE,听觉和视觉功能相关的网络.
- 在TLE-HS中,特别是叶中,SBA变化更大,突出了其独特的病理生理学和差异诊断的潜力.
更多相关视频
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
06:28Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems
Published on: September 27, 2024
相关概念视频
Magnetic Resonance Imaging
Brain Imaging
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Imaging Studies for Cardiovascular System IV: CMRI
