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化学混合物对简化人类肠道微生物群的影响:在环境现实的度下评估异生菌

Sven-Bastiaan Haange¹, Sarah Riesbeck¹, Alix Sarah Aldehoff¹

¹Helmholtz-Centre for Environmental Research - UFZ GmbH, Department of Molecular Toxicology, Leipzig, Germany.

Journal of hazardous materials

|May 31, 2024

概括

环境污染物如PFAS和双醇会破坏肠道微生物群. 暴露增加了短链脂肪酸 (SCFA) 产量和改变了代谢途径,突出了结合异生菌风险评估的必要性.

科学领域:

微生物组研究的研究.
环境毒理学环境毒理学
代谢学代谢学代谢学

背景情况:

肠道微生物组对于营养生产和宿主健康至关重要.
环境污染物 (异生菌) 可以破坏这种微妙的微生物平衡.
了解异生菌对微生物群的影响对于公共卫生至关重要.

研究的目的:

研究特定的per-和多基物质 (PFAS) 和双化合物 (BPXs) 对人类肠道微生物群的直接影响.
分析微生物新陈代谢和短链脂肪酸 (SCFA) 生产的变化.
评估这些异生菌对简化人类微生物组模型 (SIHUMIx) 的综合影响.

主要方法:

使用一个体外生物反应器模型系统 (SIHUMIx).
将模型暴露在单个和组合的异生菌中:PFOA,PFHxA,PFBA,BPS和BPF.
采用了metapeptidomics来分析微生物通路和SCFA生产中的变化.

主要成果:

暴露于PFAS导致SCFA产量增加,特别是酸盐和丁酸盐.
甲蛋白组学揭示了重要的途径变化,包括维生素合成和脂肪酸代谢,特别是在BPX暴露时.
无论是单个暴露还是联合暴露,都显示出对肠道微生物群体有可测量的影响.

结论:

异生菌,包括PFAS和BPX,直接影响肠道微生物的功能和新陈代谢.
评估环境化学品的综合作用对于准确的风险评估至关重要.
在评估环境化学品的安全性时,对微生物群的不良影响应该是关键考虑因素.

关键词:

双醇是一种双醇.甲型蛋白质组学是什么意思微生物群中的微生物群在PFAS中,有很多方法.有毒性有毒性

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