认知储备代理与与年龄相关的认知衰退有关 - 不与年龄相关的步行速度下降
Helena M Blumen1, Oshadi Jayakody2, Emmeline Ayers3
1Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Neurobiology of aging
|May 31, 2024
概括
认知储备 (CR) 保护老年人的认知能力下降. 然而,这项研究发现,CR并没有显著减缓与年龄相关的步行速度下降,这表明步行可能在以后的生活中不受CR的影响.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 认知和步行共享神经通路,两者都受到衰老和痴呆的影响.
- 认知储备 (CR) 可能缓冲认知和步态下降,但证据是混合的.
- 了解CR对与衰老相关的认知和步态变化的影响对于干预至关重要.
研究的目的:
- 研究认知储备代理和与年龄相关的认知和步行速度下降之间的关联.
- 检查认知,身体和社会CR因素是否影响非痴呆老年人认知和步态下降的速度.
主要方法:
- 对1079名没有痴呆症的老年人进行了长度研究 (LonGenity研究).
- 每年进行长达12年的随访 (平均3.9年).
- 通过代理来评估CR:教育,每日散步,体育活动,社会参与 (工作/志愿服务) 和生活情况.
主要成果:
- 高CR代理 (认知,身体,社会) 与与年龄相关的全球认知衰退速度较慢有关.
- 在高CR代理和较慢的步行速度下降之间没有发现显著的关联.
- 在没有痴呆症的老年人中,认知,身体和社会CR代理与认知衰退有关,但与步行速度的下降无关.
结论:
- 认知储备与在衰老中保持认知能力有关,但不一定与保持步行速度有关.
- 由于多因素的原因和较早的发病,在晚年,步态下降可能因CR代理物而变得不那么容易改变.
- 研究结果强调了CR,认知和步态在衰老过程中的复杂关系.
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