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针对阿尔多斯特合成酶的小分子抑制剂的新兴趋势:心血管疾病治疗的新范式

Cuiyu Guo1, Guangbing Zhang2, Chengyong Wu1

  • 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan, China; Department of Pulmonary and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, Precision Medicine Key Laboratory of Sichuan Province & Precision Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

European journal of medicinal chemistry
|May 31, 2024
PubMed
概括

针对阿尔多素合成酶 (CYP11B2) 的小分子抑制剂对治疗过多的阿尔多素条件如高血压有希望. 提高抑制剂对CYP11B1的选择性对于安全性和有效性至关重要.

关键词:
阿尔多斯特合成酶抑制剂的使用在CYP11B2中.药物设计 药物设计这就是为什么SAR SAR SAR.

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