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Updated: Jun 25, 2025

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瘤细胞通过中枢神经系统丰富的代谢物破坏免疫突触的形成

Yihong Li1, Min Huang1, Minger Wang2

  • 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China.

Cancer cell
|May 31, 2024
PubMed
概括

瘤通过模仿中枢神经系统 (CNS) 来逃避免疫监测. 过度表达的N-乙转移酶8样 (NAT8L) 和其代谢物N-乙酸 (NAA) 通过抑制自然杀手 (NK) 和CD8+T细胞,损害了抗瘤免疫力.

关键词:
瘤新陈代谢的发生抗瘤免疫力 免疫力免疫检查点封锁封锁免疫学的突触.神经炎症是一种神经炎症.

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