达沙替尼布,左心房压升高和多叶流液之间的关联
Sean Tan1, Diva Baggio2, Kylie Porch2
1Victorian Heart Hospital, Monash Health, Melbourne, Victoria, Australia; Victorian Heart Institute, Monash University, Melbourne, Victoria, Australia.
International journal of cardiology
|May 31, 2024
概括
在慢性髓性白血病 (CML) 中使用达沙替尼与肺溢液 (PE) 和左心房压力升高 (LAP) 有关. 心声图可以帮助识别患有PE风险的患者,指导进一步的调查和管理.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 像达沙替尼这样的氨酸激酶抑制剂 (TKIs) 对慢性髓性白血病 (CML) 治疗至关重要.
- 达沙提尼布治疗与多叶膜溢出 (PE) 相关,这是一个已知的并发症.
- 血液动力学参数之间的联系,特别是胸前回声图 (TTE) 上左心房压升高 (LAP) 和CML患者的PE发育之间的联系尚不清楚.
研究的目的:
- 在CML患者中调查达沙替尼使用,LAP升高和PE之间的关联.
- 描述在接受TKI治疗的CML患者中TTE上LAP升高的患病率.
- 在这个患者队列中确定LAP升高的预测因子.
主要方法:
- 在TKI治疗期间接受了TTE的71名CML患者的回顾性分析.
- 描述性统计评估TKI使用,PE和高LAP之间的关系.
- 多变量后勤回归用于确定预测LAP升高的因素.
主要成果:
- 与尼洛替尼和伊马替尼使用者相比,达沙替尼使用者的LAP (44%) 和PE (39%) 升高率显著更高.
- 在15名患有PE的患者中,有14人 (93%) 接受了达沙替尼.
- 患有PE的患者 (67%) 和没有PE的患者 (16%),LAP升高更为常见.
- 多变量分析确定达沙替尼的使用 (OR 33.50) 和年龄 (OR 1.12) 是LAP升高的显著预测因素.
结论:
- 在CML患者中,达沙替尼,TTE上LAP升高和PE之间存在关联.
- 升高的LAP可以作为预测和监测PE发展的潜在标志物.
- 需要进一步的研究来验证TTE衍生的LAP测量对CML患者PE监测的有用性.
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