通过在肠道和土壤元基因组中刻印的化合物加工潜力,对"健康微生物组"进行生物能量绘制
Craig Liddicoat1, Robert A Edwards1, Michael Roach1
1College of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.
The Science of the total environment
|May 31, 2024
概括
定义一个a.
科学领域:
- 微生物组研究的研究.
- 转基因组学是指转基因组学.
- 环境科学环境科学
背景情况:
- "健康微生物组"的定义和测量尚不清楚,尽管它们对人类健康和生态系统的重要性已知.
- 环境微生物群的暴露,特别是来自土壤的暴露,可以影响人类微生物群的功能.
- 微生物,它们的原料和微环境相互作用,功能基因驱动化学转换.
研究的目的:
- 开发定量措施来评估人类肠道和土壤微生物群的in silico潜力,以处理健康相关的化合物.
- 整合功能基因组学和生物化学框架,用于新型微生物组分析.
- 探索微生物组化合物加工潜力与人类健康/疾病以及生态系统质量之间的关系.
主要方法:
- 综合功能基因组学和生物化学框架.
- 开发了对元基因组的"复合加工潜力"的定量测量.
- 利用van Krevelen的生物能量绘图来创建一个通用的复合绘图"景观".
- 分析了人类健康和疾病病例研究 (动脉样性心血管疾病,结直肠癌,2型糖尿病,焦虑抑郁行为).
- 检查了沿生态干扰梯度 (采矿后恢复) 检查了土壤元基因组潜力的变化.
主要成果:
- 导出了微生物组"复合加工潜力"的新定量措施.
- 化合物加工潜力与人类健康/疾病状况之间的相关性.
- 观察到与生态干扰相关的土壤微生物组潜力的可预测变化.
- 发现生态系统质量解释了土壤基因组潜力变化的很大一部分 (60-92%).
结论:
- 复合加工潜力为量化微生物群在环境和人类健康中的作用提供了一种简化,综合的方法.
- 甲基因组分析可以揭示微生物组代谢健康相关化合物的能力.
- 可以设计环境干预措施和自然处方来调节暴露,并推进以微生物群为导向的健康方法.
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