装有生物纳米复合材料的多功能聚乙醇/聚多巴胺水凝通过修复内源电场来促进伤口愈合
Yueyuan Zhu1, Xiuwen Zhang1, Ren Li1
1College of Environment and Safety Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Shandong Engineering Research Centre for Marine Environment Corrosion and Safety Protection, Qingdao University of Science and Technology, Qingdao 266042, China; Shandong Engineering Technology Research Centre for Advanced Coating, Qingdao University of Science and Technology, Qingdao 266042, China.
International journal of biological macromolecules
|May 31, 2024
概括
一种新的心形纳米复合材料 (MXene@Cu-MOF) 增强了水凝伤口包裹. 这种改进的材料促进细菌生物膜的破坏和电导性,显著加速慢性伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 伤口治愈研究研究 伤口治愈研究
背景情况:
- 传统的伤口往往缺乏先进的功能,如电导率和强大的抗菌作用.
- 像MXene这样的纳米材料的积累可以阻碍它们的有效性和整合到矩阵中.
- 恢复慢性伤口中的自然电场对于有效的愈合至关重要.
研究的目的:
- 开发一个心形纳米复合材料 (MXene@Cu-MOF,MC),以克服MXene积累并增强材料特性.
- 将MC纳米复合材料纳入聚乙烯醇/聚多巴胺水凝 (PPMC) 中,用于先进的伤口合应用.
- 通过评估抗菌性,导电性和细胞迁移性质,评估PPMC水凝在促进慢性伤口愈合方面的有效性.
主要方法:
- MXene@Cu-MOF (MC) 纳米复合物的水热合成.
- 将MC加载到聚乙烯醇/聚多巴胺水凝中,以制造PPMC伤口敷料.
- 通过度梯度实验评估水凝特性,包括抗菌活性,电导率,生物相容性 (血解) 和细胞迁移.
主要成果:
- 这种MC纳米复合材料有效地阻止了MXene的聚合,提高了电导率和抗菌功效.
- 与对照组相比,PPMC水凝表现出增强的抗菌特性,生物膜破坏性和电导性.
- PPMC0.2配方表现出最佳性能,抗性在500-1000 Ω之间 (低于皮肤),在24小时内58%的细胞迁移,在6天内81.84%的伤口愈合率,所有这些都保持了生物相容性.
结论:
- 开发的PPMC水凝,结合MC纳米复合材料,显著改善了水凝的伤口愈合特性.
- PPMC 水凝通过促进电流通道和促进组织修复,为慢性伤口管理提供了一个有希望的新疗法策略.
- 这项研究提出了慢性伤口愈合的新方法,突出了功能化纳米复合材料水凝的潜力.
相关概念视频
Long-patch Base Excision Repair
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Overview of Regeneration and Repair
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
Phases of Wound Repair
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Fractures: Bone Repair
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Healing I: Introduction
Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...


