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在慢性疼痛中奖励延迟满足和冲动性的轨道向编码

Mariana Cerqueira-Nunes¹, Clara Monteiro², Vasco Galhardo²

¹Instituto de Investigação e Inovação em Saúde (i3S) - Pain Neurobiology Group, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; Faculdade de Medicina, Departamento de Biomedicina - Unidade de Biologia Experimental (FMUP), Universidade do Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal; Programa doutoral em Neurociências (PDN), Faculdade de Medicina, Universidade do Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.

|May 31, 2024

概括

慢性疼痛会破坏大脑网络,影响诸如奖励和时间感知等认知功能. 这篇综述探讨了轨道前皮层和核的变化如何导致这些障碍.

科学领域:

神经科学是一个神经科学.
行为科学行为科学

背景情况:

中枢神经系统的功能重组是神经系统疾病的特征,包括慢性疼痛.
轨道前皮层 (OFC) 和核 (NAc) 的功能障碍与慢性疼痛中的认知缺陷有关.
轨道三层回路对于处理结果信息和编码上下文依赖的奖励值至关重要.

研究的目的:

为了提供一个全面的概述的轨道三叶道机制在时间奖励行为.
在慢性疼痛的背景下整合有关形性的发现.
为了阐明慢性疼痛相关认知障碍的潜在障碍.

主要方法:

临床前和临床研究的文献综述.
分析轨道三交叉声的结构和功能变化.
整合网络塑性发现.

主要成果:

慢性疼痛与轨道前道的结构和功能变化有关.
这些变化可能是奖励和时间歧视的基础.
这个网络中的不良可塑性是慢性疼痛相关行为障碍的关键因素.

结论:

轨道底性网络功能障碍与慢性疼痛相关的认知缺陷有关.
了解这些机制对于解决奖励和时间感知障碍至关重要.
需要进一步的研究,以充分阐明潜在的病理过程.

关键词:

决策方式决策方式核积累的中心 (nucleus accumbens) 是一个核.轨道前额皮层的皮层.轨道三叶道的电路.与疼痛相关的神经可塑性奖励的价值是奖励的价值.

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