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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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相关实验视频

Updated: Jun 25, 2025

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

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微质细胞和TREM2的使用

Jennifer Pocock1, Foteini Vasilopoulou1, Elina Svensson1

  • 1Department of Neuroinflammation, And Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, 1 Wakefield Street, London, WC1N1PJ, UK.

Neuropharmacology
|May 31, 2024
PubMed
概括

在骨髓细胞2 (TREM2) 上表达的触发受体对于大脑中的微质功能至关重要. 研究强调TREM2在阿尔茨海默氏症和帕金森症等神经退行性疾病中的作用,使用iPSC模型了解其机制.

科学领域:

  • 神经免疫学 神经免疫学
  • 细胞生物学 细胞生物学
  • 神经退行性疾病研究研究

背景情况:

  • TREM2是一种微质受体,对大脑的恒温至关重要.
  • TREM2功能障碍与神经退行性疾病有关,包括阿尔茨海默氏症和FTD.
  • 从iPSC衍生的微质细胞 (iMG) 提供了一个在人类疾病中研究TREM2的模型.

研究的目的:

  • 审查TREM2生物学的最新进展及其对微质功能的影响.
  • 要强调来自具有TREM2功能丧失突变的iPSC衍生微质的发现.
  • 探索TREM2在各种神经退行性疾病中的作用.

主要方法:

  • 关于TREM2生物学和信号的当前文献的综述.
  • 分析来自iPSC衍生微质细胞 (iMG) 模型的数据.
  • 讨论TREM2的下游功能和临床相关性.

主要成果:

  • TREM2信号改变与FTD和AD的风险变异有关.
  • TREM2调解了碎片,粉样蛋白和应激细胞的微细胞.
  • TREM2影响微质的生存,迁移和炎症反应.

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In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
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Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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Last Updated: Jun 25, 2025

Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
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In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
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In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages

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Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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结论:

  • 在微质对损伤的反应和神经保护中,TREM2发挥着多方面的作用.
  • 对于剖析TREM2对神经退行性疾病机制的贡献,iPSC模型是非常宝贵的.
  • 了解TREM2是开发AD,PD,MS和ALS治疗方法的关键.