在怀孕期间接触BPA和BPS会破坏后代的骨矿化
Saikanth Varma1, Archana Molangiri1, Sreedhar Mudavath2
1Molecular Biology Division, ICMR-National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India.
概括
孕期对双A (BPA) 和双S (BPS) 的暴露增加了后代的骨矿物质含量和密度. 这可能是通过骨形态遗传蛋白和信号介质的改变表达而发生的.
科学领域:
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 塑料衍生的内分泌干扰双,如BPA和BPS,是雌激素模仿物.
- 孕期双暴露对后代骨健康的长期影响尚未完全理解.
研究的目的:
- 调查子宫内暴露于BPA和BPS对后代骨参数的影响.
- 阐明导致骨矿化发生双醇诱导的变化的分子机制.
主要方法:
- 怀孕的Wistar大鼠在怀孕期间 (4-21天) 通过口腔输液给BPA和BPS (0.0,0.4μg/kg bw).
- 后代的骨矿物质含量和密度在30天和90天后进行评估.
- 在骨质细胞中分析了等离子体标记物 (性酸酶,骨质卡尔) 和基因表达 (BMP,SMAD,细胞外矩阵蛋白).
主要成果:
- 母亲BPA和BPS暴露显著增加后代的骨矿物质含量和密度在30和90天.
- 暴露于BPS的后代表现出血性酸酶和Gla型骨质卡尔辛的升高.
- 在暴露于BPS的骨质细胞中,BMP1,BMP4,SMAD1,ALPL,COL1A1,DMP1和FN1的表达下调.
结论:
- 孕期暴露于BPA和BPS会改变后代的生长和骨矿化.
- 双暴露可能会破坏骨形态蛋白和TGF-β1信号通路的调节,影响骨质细胞功能和骨形成.
- 这些发现凸显了在关键发育时期内内分泌干扰化学物质的潜在风险.
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