术前骨质疏松症与乳腺癌患者的预后之间的关联
Sachie Omori1,2, Hideki Ijichi3,2, Ayako Wakasugi3,2
1Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; omori.sachie12@gmail.com.
Anticancer research
|May 31, 2024
概括
手术前的骨质疏松症,即骨矿物质密度的下降,与乳腺癌复发率的增加有关,特别是在绝经前妇女中. 这一发现强调了骨质疏松症是乳腺癌存活率的重要预后因素.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 骨质疏松症的特征是骨矿物质密度降低 (BMD),是各种癌症的新兴预后因素.
- 乳腺癌患者手术前骨质疏松症的预后作用尚未得到充分证实.
- 澄清这种关联对于改善乳腺癌患者的治疗结果至关重要.
研究的目的:
- 研究术前骨质疏松症作为原发性乳腺癌的预后因素的临床意义.
- 为了确定骨质疏松症和患者存活率之间的关系,考虑到更年期状态.
主要方法:
- 对532名在2009年至2017年期间被诊断为原发性乳腺癌患者 (I-III期) 的回顾性分析.
- 在手术前的CT扫描中,使用第11个胸椎的平均像素密度 (Hounsfield单位) 评估骨质疏松症.
- 与骨质疏松症状况和更年期状况相关的无复发生存 (RFS) 和整体生存 (OS) 的评估.
主要成果:
- 在35.0%的患者中存在骨质疏松症.
- 患有骨质疏松症的患者的RFS明显恶化 (p=0.0275),但不是OS.
- 在更年期前的患者中,骨质疏松症与显著恶化的RFS和OS有关 (分别为p=0.0094和p=0.0264),并且是RFS的独立预后因素 (p=0.0266).
结论:
- 手术前的骨质疏松症独立地与乳腺癌复发风险增加有关.
- 骨质疏松症的预后影响在绝经前乳腺癌患者中尤为显著.
- 这些发现表明,骨质疏松症评估可能有助于乳腺癌复发风险分层.
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