在全身性死性血管炎的严重感染.
Claudia Pena1, Ana Carolina Costi1, Lucila García1
1Hospital Interzonal General de Agudos General José de San Martín, La Plata, Buenos Aires, Argentina.
Reumatologia clinica
|May 31, 2024
概括
严重的感染在血管炎患者中很常见,影响34.2%并增加死亡风险. 关键因素包括年龄较大,肺/参与,以及高的疾病活动得分.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 临床医学 临床医学
背景情况:
- 感染是系统性血管炎患者死亡的主要原因.
- 感染的危险因素包括皮质类固醇使用,免疫抑制,年龄,器官参与和透析依赖.
研究的目的:
- 为了确定患有ANCA相关血管炎 (AAV) 和多关节炎 (PAN) 的患者严重感染的患病率.
- 确定这些患者群体中与严重感染相关的因素.
主要方法:
- 从2000年到2018年,在单一的风湿病中心进行了一项回顾性研究.
- 包括被诊断患有AAV (GPA,EGPA,PAM) 和PAN的患者.
- 评估了严重的感染事件,感染地点,致病微生物和死亡率.
主要成果:
- 34.2%的患者经历了严重的感染,诊断血管炎后3个月的中位数.
- 最常见的感染地点是下呼吸道 (42.8%),败血症 (31.4%) 和尿道 (14.3%).
- 感染与年龄>65岁,肺/脏参与和BVAS评分>15显著相关.
结论:
- 在AAV和PAN患者中,严重感染的患病率为34.2%.
- 最常见的是下呼吸道感染,败血症和尿路感染.
- 严重的感染与死亡率的增加有关,特别是在有重大器官干扰和高疾病活性的老年患者中.
相关概念视频
Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K
Inflammation
53.3K
Overview
53.3K
Burn Injuries
2.5K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.5K


