目前的风景的静脉动试验:注册研究的系统审查注册研究
Anunay Gupta1, Vlad Danaila2, Kasun De Silva1
1Department of Cardiology, Westmead Hospital, NSW, Australia; Westmead Applied Research Centre, University of Sydney, NSW, Australia.
Heart, lung & circulation
|May 31, 2024
概括
对于心室低心率 (VT) 管理的临床试验尚未进行研究. 许多试验仍然未发表或不完整,随机对照试验证据有限,需要进行更大规模的研究.
科学领域:
- 心脏病学 心脏病学
- 临床试验 临床试验
- 电力生理学 电力生理学
背景情况:
- 风性心动减速 (VT) 的管理正在发展.
- 静脉治疗的临床试验环境还没有得到充分的研究.
研究的目的:
- 系统地描述干预性VT管理.
- 分析全球临床试验数据库 (ClinicalTrials.gov,EU CTR,ANZCTR,CTCTR) 的情况.
主要方法:
- 搜索了截至2023年11月的II-IV期干预性体检试验的数据库.
- 包括已发表,未发表,已终止和正在进行的试验.
主要成果:
- 分析了来自698项注册研究的123项VT试验.
- 只有25%的试验被发表,随机化有限 (56%).
- 目前正在进行的试验越来越多地侧重于非废除疗法 (放射废除,自主调节).
结论:
- 许多注册的VT试验仍然未公布或不完整.
- 有限的随机对照试验证据存在于VT干预.
- 未来的研究需要更大的实用试验,特别是对于新的非消灭性策略.
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