铁素系统通过对核糖核酸还原酶活性的氧化还原介导调节来确定CHK1抑制剂的敏感性

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Chandra Bhushan Prasad1, Adrian Oo2, Yujie Liu1

  • 1Department of Radiation Oncology, James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Columbus, OH, 43210, USA.

Nature communications
|May 31, 2024
PubMed
概括

检查点激酶1 (CHK1) 抑制剂在非小细胞肺癌 (NSCLC) 治疗中表现有前途. 将CHK1抑制剂与抗氧化药物auranofin结合起来,通过向脱氧核酸池来提高疗效.

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