过度活跃的膀与全身免疫炎症指数之间的关联:NHANES 2005年至2018年的横截面研究
Baian Wei1, Ying Zhao1, Pinli Lin1
1The Second Clinical College of Guangzhou, University of Chinese Medicine, Guangzhou, China.
Scientific reports
|May 31, 2024
概括
较高的全身免疫-炎症指数 (SII) 水平与过度活性膀 (OAB) 风险的增加相关. 这项研究发现,在美国成年人中,SII升高和OAB发展的可能性更高之间存在显著的关联.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 炎症越来越被认为是导致过度活跃膀 (OAB) 发展的因素.
- 系统性免疫-炎症指数 (SII) 是一个反映系统性炎症和免疫细胞平衡的标记.
- 了解炎症标志物和OAB之间的关系对于识别潜在的风险因素至关重要.
研究的目的:
- 调查系统性免疫-炎症指数 (SII) 与在美国大人口中过度活跃膀 (OAB) 的患病率之间的联系.
- 确定较高的SII水平是否与OAB风险增加独立相关.
主要方法:
- 分析了2005-2018年国家健康和营养检查调查 (NHANES) 31,881名参与者的数据.
- 使用血小板计数,中性粒细胞计数和淋巴细胞计数计算SII,分为四分位数.
- 使用加权后勤回归模型来评估SII和OAB之间的关系,并根据各种混因素进行调整.
主要成果:
- 在SII水平和OAB之间观察到显著的正相关性.
- 每一次日志化SII的十倍增长都与OAB (OR 1.18) 的概率提高18%有关.
- 与最低四分位数相比,SII四分位数最高的参与者表现出OAB风险增加了28%.
结论:
- 系统性免疫-炎症指数 (SII) 水平升高与患有过度活性膀 (OAB) 的风险增加有关.
- 这些发现表明,SII可能作为OAB风险的潜在生物标志物.
- 需要进一步的研究来探索关联炎症和OAB的潜在机制.
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