胎盘病理和胎儿生长结果在妊娠中,由母亲肥胖症复杂的孕妇
Samantha Hietalati1, Donna Pham2, Harneet Arora2
1Department of Pediatrics, Division of Neonatology, University of California San Diego, La Jolla, CA, USA.
International journal of obesity (2005)
|May 31, 2024
概括
孕产妇肥胖会增加胎盘损伤,降低胎盘效率,但婴儿出生体重百分比上升. 这表明高风险怀孕中胎儿和胎盘的复杂适应性.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 病理学 病理学 病理学
背景情况:
- 增加的孕产妇肥胖率带来了产科并发症和新生儿后果的风险.
- 了解肥胖对胎盘功能和胎儿发育的影响对于高风险怀孕至关重要.
- 这项研究调查了母体体重指数 (BMI) 的升高如何影响胎盘病理和胎儿生长.
研究的目的:
- 为了确定母体BMI升高对胎盘损伤的基因病学模式的影响.
- 评估这些胎盘变化对胎儿生长和婴儿后果的影响.
- 探索孕产妇肥胖,胎盘病理和出生体重百分点之间的关系.
主要方法:
- 来自UCSD妇产科注册中心 (2011-2020) 的1366个母婴二位数的分析.
- 收集关于母亲的BMI,高血压疾病,糖尿病,胎盘病理和婴儿特征的数据.
- 使用ANOVA,奇平方测试,日志二项式和线性回归模型进行统计分析,并对混因子进行调整.
主要成果:
- 来自超重/肥胖母亲的胎盘显示慢性小炎增加,垂体血管病变,间血栓形成和正常血.
- 胎盘效率 (胎儿-胎盘体重比) 随着母亲的BMI增加而下降.
- 孕产妇肥胖与更高的早产率和增加的出生体重百分比有关;孕产妇血管输血 (MVM) 基于肥胖症产生了差异效应.
结论:
- 怀孕期间的肥胖与胎盘损伤增加,胎盘效率降低和出生体重百分比较高有关.
- 虽然胎盘病变会对胎儿生长产生负面影响,但观察到的出生体重模式表明了复杂的胎盘-胎盘适应.
- 需要进一步的研究,以充分理解孕妇肥胖症复杂的怀孕中的适应机制.
相关概念视频
Pathophysiology of Diabetes
920
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
920
Obesity
453
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
453
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Teratogenicity
2.4K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.4K
Fetal Circulation
932
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
932


