大脑网络的拓组织在患有初级闭角玻璃眼患者通过图形理论分析
Ri-Bo Chen1, Xiao-Tong Li2, Xin Huang3
1Department of Radiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, Jiangxi, China.
Brain topography
|May 31, 2024
概括
主要闭角光眼 (PACG) 改变了大脑的功能网络,特别是在特定区域,但不是整体的全球连接. 这些发现可能有助于早期诊断和针对PACG患者的向治疗.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 医疗成像医学成像
背景情况:
- 主要闭角光眼 (PACG) 是不可逆转失明的主要原因.
- 之前的研究表明,PACG患者的大脑功能异常.
- PACG对功能性大脑网络的影响仍然未被探索.
研究的目的:
- 为了研究PACG对大脑功能网络的影响.
- 确定神经生物学基础,以改善PACG的诊断和治疗.
- 利用图形理论分析进行全面的网络评估.
主要方法:
- 44名PACG患者和44名健康对照组的功能磁共振成像 (fMRI) 数据.
- 使用自动化解剖标记90模板构建功能性大脑网络.
- 应用图形理论分析来评估全球,节点和模块化网络属性,包括基于网络的统计 (NBS).
主要成果:
- 在PACG患者和对照人群之间,全球网络指标 (小世界性,效率) 没有显著差异.
- PACG患者表现出前后中央区域的节点指标 (中心性,效率) 发生变化,上环节的值下降.
- 在模块内部连接 (模块5) 和模块间连接 (模块1与模块7和8) 中观察到显著的差异. 在PACG中,NBS揭示了在PACG中显著改变的网络.
结论:
- PACG与功能性大脑网络中的节点指标和模块化组织的特定变化有关,影响前额,,和小脑区域.
- 总体而言,全球大脑网络连接在PACG患者中似乎不受影响.
- 这些网络变异可能作为PACG的早期诊断标记,指导治疗干预对受影响的大脑区域.
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